What is Flavopiridol?

Flavopiridol is a constructed flavone admixture that inhibits the phosphorylation of cyclin-dependent kinases (Cdks) and suppresses announcement of cyclin D1 and D3, arresting the axial role of Cdks in the adjustment of the corpuscle aeon and appropriately announcement apoptosis. This activity has been exploited in studies investigating the abolishment of oncogenic proliferation, synovial hyperplasia, and collective abolition accompanying to rheumatoid arthritis. Flavopiridol is an inhibitor of Cdk1, Cdk10, Cdk11, Cdk2, Cdk3, Cdk4, Cdk5, Cdk6, Cdk7, Cdk8 and Cdk9.

Flavopiridol is an important beginning drug, acquired from a alleviative bulb from India which has been acclimated for centuries in abounding aboriginal medicines. Flavopiridol is getting developed by Aventis Oncology in accord with the National Cancer Institute (NCI). Its use is anon beneath analysis for a array of solid tumors as able-bodied as hematological cancers. Several actual ablaze advisers whose horse faculty I assurance assume to anticipate this biologic has "legs", that it will survive the aboriginal appearance enhancement trials to become a above biologic for the analysis of CLL.