What is Sophoricoside?

Sophoricoside (SOPH) is an isoflavone abandoned from Sophora japonica (Leguminosae). In this study, the inhibitory aftereffect of SOPH on acquaintance dermatitis was investigated. At dosages of 3 and 10 mg/kg, SOPH ameliorated 2,4-dinitrochlorobenzene-induced astute and abiding acquaintance dermatitis by 50–70%. As cellular targets, SOPH mainly afflicted the functions of B beef rather than T cells, macrophages and blooming cells. As signaling targets, SOPH inhibited the phosphorylation and abasement of IκBα/β and the nuclear about-face of NF-κB p65 in B cells, but not in blooming beef and macrophages. SOPH did not affect the phosphorylation of ERK, p38, and JNK MAPKs, in B cells, blooming cells, and macrophages. Taken together, these after-effects advance that SOPH ameliorates acquaintance dermatitis by inhibiting mainly NF-κB signaling in B cells.